Activated protein C is the only drug with FDA approval specifically for treatment of sepsis. Prospective observational studies demonstrated an absolute decrease in the level of activated protein C in some patients with severe sepsis and a subsequent increase in mortality. However, there is much debate as to its efficacy.
What is standard practice in your hospital? Are you using rH-APC — why or why not?
Keep in mind: APC is only FDA approved for patients with an APACHE score greater than 25. An online APACHE calculator is available at www.mdcalc.com/apacheii.
